Objective: This review aims to determine the impact of different drugs and\nmethods on the successful establishment of an animal model for chemical\nphlebitis (CP). Design: Search the Cochrane Library, ProQuest Academic\nJournal Library, PubMed, Web of Science, Ovid, Embase, CINAHL complete\n(EESCO) and other related databases to determine the literature. Screen out\narticles consistent with this review and summarize them. Results: Since the\nestablishment of the database, a total of 1463 articles have been retrieved. After\nreading the title, abstract and full text, and excluding non-related and\nduplicate articles, 22 reports were finally included. Among them, there are 8\narticles using different medication methods to compare the effects of establishing\na CP model. The included articles explored the effects of different\nanimal models, drug types, and their dose, concentration, speed, and time on\nthe CP model. Conclusion: The factors of dose, concentration and time were\npositively correlated with the incidence of CP. The effect of speed factors on\nCP and the results of different animal models are inconsistent. It requires\nfurther research in the future.
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